Desmopressin nasal spray 10 microgramsdose leaflet. Desmopressin also known as ddavp, which stands for. If you use other drugs or over the counter products at the same time, the effects of desmospray desmopressin nasal spray may change. Throw away any unused medicine after 25 sprays stimate or 50 sprays ddavp or desmopressin generic. Jan 23, 2019 desmopressin should be used with caution in pregnant women. Desmopressin nasal spray is used to treat central cranial diabetes insipidus. Ddavp nasal spray desmopressin acetate rx only description ddavp nasal spray desmopressin acetate is a synthetic analogue of the natural pituitary hormone 8arginine vasopressin adh, an antidiuretic hormone affecting renal water.
Desmospray desmopressin nasal spray uses, sideeffects. Ddavp tablets desmopressin acetate dose, indications. Be alert for an imbalance in body water and electrolytes that results in low sodium levels hyponatremia. The rise in vwf in the blood can help raise the amount of factor viii, it may also help some people with mild hemophilia. Management view in chinese with oral desmopressin, it is recommended that fluid intake be limited to eight ounces 240 ml from one hour before to eight hours after administration of desmopressin. Ddavp nasal spray is contraindicated in individuals with known hypersensitivity to desmopressin acetate or to any of the components of ddavp nasal spray. The hormone works on the kidneys to control frequent urination. Desmopressin is a manmade form of a hormone that occurs naturally in the pituitary gland. Desmopressin nasal spray 10 microgramsdose have syndrome of inappropriate adh secretion siadh.
May 24, 2017 the aim of this study was to describe the use of orally administered dilute desmopressin in ncdi. Desmopressin acetate is a drug that causes vwf that is stored in the lining of blood vessels to be released into the bloodstream. Although ddavp is given subcutaneously in most patients, it can also be administered by intravenous infusion or by nasal. Ddavp contains as active substance desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. Read more about the prescription drug desmopressin 0. When switching from the desmopressin acetate tablets to ddavp nasal spray individual dose titration is required because intranasal desmopressin is approximately 10 to 40 fold. Desmopressin nasal spray fda prescribing information, side. Desmopressin acetate nasal spray msds special notice. Us5498598a composition for nasal administration of. Ddavp nasal spray, solution drug information, side effects. Nasal desmopressin is also used to control excessive thirst and the passage of an abnormally large amount of urine that may occur after a head injury or after certain types of surgery. This hormone affects blood pressure, kidney function, and regulating how the body uses water. Development of validated pre column hplcfluorescence method. Although ddavp is given subcutaneously in most patients, it can also be administered by intravenous infusion or by nasal spray.
Desmopressin lyophilisate for the treatment of central. Ddavp nasal spray is not an indicated formulation for the treatment of primary nocturnal enuresis due to a higher risk of hyponatremia and hyponatremic convulsions with the use of the nasal spray formulation compared to desmopressin tablets seen in. Lowdose desmopressin nasal spray and fda approval jama. Ddavp is contraindicated in patients with moderate to severe renal impairment defined as a creatinine clearance below 50mlmin. Intravenous or intranasal administration of desmopressin to healthy. An aqueous composition for spray nasal administration of a synthetic analog of vasopressin desmopressin. The composition may additionally contain an osmoticpressure controlling agent, such as sodium chloride, a preservative, such as chlorobutanol or benzalkonium chloride, and a buffer.
The rhinal tube applicator is a soft, flexible plastic tube with numbers printed on the side. Desmopressin nasal is used to treat central cranial diabetes insipidus, and increased. It is also used to control frequent urination and increased thirst caused by certain types of brain injury or brain surgery. Unlike the natural antidiuretic hormone, desmo pressin produces little or no vasoconstriction, no increase desmopressin ddavp in the. The name of your medicine is desmopressin spray, 10 microgramsdose, nasal spray, solution referred to as desmopressin spray throughout this leaflet. Noctiva desmopressin acetate nasal spray is available in a 3.
Ddavp is only used in patients that have some level of fviii or vwf in their plasma. The feed volume was 150 mlkgday and titrated according to weight gain. Pdf two new modes of desmopressin ddavp administration. Desmopressin acetate nasal spray is not an indicated formulation for the treatment of primary nocturnal enuresis due to a higher risk of hyponatremia and hyponatremic convulsions with the use of the nasal spray formulation compared to desmopressin tablets seen in postmarketing reports see indications and usage 1. These situations include nasal congestion and blockage, 76. Ddavp does not affect factor ix fix levels and is not used to treat hemophilia b how is desmopressin used. Desmopressin acetate has been shown to be more potent than arginine vasopressin in increasing. Desmopressin acetate nasal spray stimate is a synthetic analogue of the natural pituitary hormone 8arginine vasopressin adh, an antidiuretic hormone affecting renal water conservation. How do you treat bleeding disorders with desmopressin. Comparison of intranasal and oral desmopressin for nocturnal. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Desmopressin is only to be administered by 2 accredited rns aum, cns, tsn or parents who are competent and confident, ensuring the following 3 criteria have been achieved. Nocdurna prescribing information ferring pharmaceuticals. One brand of desmopressin nasal spray stimate is used to stop bleeding in people who have certain bleeding disorders.
Links to pubmed are also available for selected references. Your medicine is called ddavp desmopressin intranasal solution. No matter how you take desmopressin, its very important to make sure you are trained by a. Desmopressin acetate trihydrate 62357862 not listed not listed desmopressin acetate nasal spray holds 50 sprays with the right amount of medicine in each spray. Ddavp desmopressin 100 microgramsml nasal drops, solution. It contains desmopressin acetate,an antidiuretic reduces urine production. Two new modes of desmopressin ddavp administration.
This will allow the resumption of a more normal lifestyle with a decrease in urinary frequency and nocturia. Desmopressin nasal is used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or. Desmopressin des moe press in is a man made hormone. Fda approval of desmopressin for nocturia nephrology. Desmopressin is a synthetic analog of the natural pituitary hormone arginine vasopressin, an antidiuretic hormone affecting renal water conservation. Ddavp desmopressin response test churchill hospital. Compare ddavp vs desmopressin comprehensive analysis by. Description ddavp desmopression intranasal solution is a medicine for nasal use only.
Oct 01, 2018 desmopressin acetate nasal spray solution, 10 mcg0. For more information available for free download from. Desmopressin nasal route national library of medicine. Signs include headache, confusion, listlessness, fatigue, irritability, muscle abnormalities weakness, cramps, spasms, and decreased consciousness that can progress to coma and seizures. Throw away your desmopressin acetate nasal spray after 50 sprays. We will continue to use fair share allocation of otc product to combat shortages and strive to get orders out in a timely manner. Desmopressin spray is used to treat diabetes insipidus. On march 3, 2017, the us food and drug administration fda approved desmopressin nasal spray noctiva for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void. Desmopressin nasal spray fda prescribing information. Nasal spray desmopressin ddavp for mild hemophilia a and. Desmopressin was introduced for the treatment of cdi first in 1972 and has been commercially available for many years as an intranasal solution 1972, an injectable solution for intravenous, subcutaneous or intramuscular use 1981, a nasal spray 1986 and oral solid tablet 1987.
Ddavp intranasal solution contains the active ingredient desmopressin, which is a type of medicine called a vasopressin analogue. The use of desmopressin acetate nasal spray solution in patients with an established diagnosis will result in a reduction in urinary output with increase in urine osmolality and a decrease in plasma osmolality. Click here to read more about desmopressin, which is also available under the brand names minirin nasal and stimate nasal. Ddavp nasal spray desmopressin acetate nasal spray. If any medicine is left in your desmopressin acetate nasal spray after 50 sprays, do not use it. It is used in patients after a head injury or some surgeries. Desmopressin nasal may cause serious and possibly lifethreatening hyponatremia low level of sodium in your blood. Ddavp nasal spray desmopressin acetate nasal spray is available in a 5ml bottle with spray pump delivering 50 sprays of 10 mcg ndc 0075245201. Desmopressin acetate nasal solution nasal spray is a prescription medicine called a vasopressin analog used as an antidiuretic replacement to manage central diabetes insipidus. It is similar to a hormone produced naturally by the body, called. Consumer information about the medication desmopressin 0. Desmopressin acetate is a synthetic analogue of the natural hormone arginine vasopressin. Desmopressin acetate trihydrate 62357862 not listed not listed desmopressin ddavp administration. Given high and fixed dosage of nasal spray, intranasal.
This medicine is used to treat central diabetes insipidus. Ddavp desmopressin intranasal solution desmopressin acetate. Two new modes of desmopressin ddavp administration article pdf available in british medical journal 2806225. This is a condition that causes the body to lose too much fluid and become dehydrated. Oral administration of diluted nasal desmopressin in managing. Desmopressin free base represents 89% of the desmopressin acetate content. Dec 01, 2019 desmopressin acetate nasal solution nasal spray is a prescription medicine called a vasopressin analog used as an antidiuretic replacement to manage central diabetes insipidus. Nov 15, 2019 desmopressin acetate nasal spray is a vasopressin analog indicated as antidiuretic replacement therapy in the management of central diabetes insipidus for adults and pediatric patients 4 years of age and older. Find patient medical information for ddavp nasal on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Desmopressin acetate will also stop bleeding in patients with hemophilia a with episodes of 84 spontaneous or traumainduced injuries such as hemarthroses, intramuscular hematomas or.
Desmopressin acetate nasal solution nasal spray is not effective in the treatment of nephrogenic diabetes insipidus. Although lowdose desmopressin nasal spray is approved for patients with nocturia and nocturnal polyuria 80% of patients with nocturia, it also showed efficacy in the small group without nocturnal polyuria. Tell your doctor if you have or have ever had a low level of sodium in your blood, are thirsty much of the time, drink large amounts of fluids, or if you have syndrome of inappropriate antidiuretic hormone siadh. The composition may additionally contain an osmoticpressure controlling agent, such as sodium chloride, a preservative, such as chlorobutanol or benzalkonium chloride, and a buffer stabilizing the ph between about 4 and 6. Desmopressin acetate is also available as ddavp rhinal tube, a refrigerated product with 2. Serum sodium is 145mmoll reference range 5 145mmoll. Desmopressin can also be used in patients with less severe di who do not want nocturnal enuresis in children.
Ddavp desmopressin intranasal solution desmopressin. What ddavp desmopressin intranasal solution is and what it is used for this medicine is for nasal use only. Desmopressin therapy without concomitant adjustment of fluid intake may lead to fluid retention and hyponatraemia, accompanied by symptoms such as weight gain, headache, nausea and oedema. It may be given in the nose, by injection into a vein, by mouth, or under the tongue. Your desmopressin acetate nasal spray has been filled with extra medicine for your priming sprays. Jun 27, 2017 ddavp nasal spray desmopressin acetate nasal spray is available in a 5ml bottle with spray pump delivering 50 sprays of 10 mcg ndc 0075245201. Ddavp nasal spray, solution drug information, side effects, faqs. Appropriate studies performed to date have not demonstrated pediatricspecific problems that would limit the usefulness of desmopressin nasal spray to treat central diabetes insipidus in children 3 months of age and older for desmopressin acetate or in children 4 years of age and older for ddavp. It is a clear, colourless solution for nasal use only. Desmopressin spray 10 microgramsdose nasal spray solution. Le medicament sadministre au moyen dun vaporisateur nasal.
It is used to diagnose and treat cranial diabetes insipidus a condition which cause extreme thirst and the continuous production of large volumes of dilute urine. The article states that serenity pharmaceuticals developed the product only to charge a higher price for an old drug. This trial was therefore undertaken to assess the value of ddavp as a nasal spray in a group of women for whom nocturia. Full text full text is available as a scanned copy of the original print version. Nocdurna is a vasopressin analog indicated for the treatment of nocturia. Desmopressin nasal solution fda prescribing information. Dec 11, 2014 the pne indication has been removed from all desmopressin nasal spray products because of an increased risk of adverse effects compared with the oral formulation which remains available for. Sep 11, 2019 when switching from the desmopressin acetate injection to ddavp nasal spray, administer 10 times the amount of desmopressin acetate, rounding down to the nearest 10 mcg. Desmopressin acetate nasal spray is provided as an aqueous solution for. Pdf oral desmopressin in neonatal diabetes insipidus. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water. Find patient medical information for desmopressin nasal on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
1371 1132 421 549 1513 1400 433 1515 1428 692 827 167 148 1405 1482 500 1376 482 242 221 1605 60 330 708 1501 752 1089 510 902 316 1564 798 522 553 1426 700 182 996 927 959 205 21 759